HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-(3,5-difluorophenyl)ethyl-N-[(3,4-dimethoxy-5-nitrophenyl)-(4-methoxyphenyl)methyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | HCID 18334221 | HCID 18334221 | — |
| Reactant | 1-(3,5-Difluorophenyl)ethanamine hydrochloride | HCID 18347036 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-(3,5-difluorophenyl)ethyl-N-[(3,4-dimethoxy-5-nitrophenyl)-(4-methoxyphenyl)methyl]amine | HCID 18347048 | 91.4% |
Reaction Steps
Following a similar procedure to that described in Example (1a), 750 mg of 3,4-dimethoxy-5-nitrophenyl 4-methoxyphenyl ketone, 915 mg of 1-(3,5-difluorophenyl)ethylamine hydrochloride, 1.98 ml of triethylamine, 0.31 ml of titanium tetrachloride, 660 mg of sodium cyanoborohydride and 0.20 ml of acetic acid were reacted, to obtain 990 mg of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-5d6affbdf54448e796c7783a29a4bb76 |
| Source note | uspto-grants-2001_12 |