HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[1-(3,5-Difluorophenyl)ethyl]-N-[(2-methoxy-5-nitrophenyl)-(4-methoxyphenyl)methyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 1-(3,5-Difluorophenyl)ethanamine hydrochloride | HCID 18347036 | — |
| Reactant | 2-Methoxy-5-nitrophenyl 4-methoxyphenyl ketone | HCID 70188099 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-[1-(3,5-Difluorophenyl)ethyl]-N-[(2-methoxy-5-nitrophenyl)-(4-methoxyphenyl)methyl]amine | HCID 18334175 | 92.5% |
Reaction Steps
Following a similar procedure to that described in Example (1a), 1.29 g of 2-methoxy-5-nitrophenyl 4-methoxyphenyl ketone, 1.74 g of 1-(3,5-difluorophenyl)ethylamine hydrochloride, 3.76 ml of triethylamine, 0.59 ml of titanium tetrachloride, 1.25 g of sodium cyanoborohydride and 0.39 ml of acetic acid were reacted, to obtain 1.78 g of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-685fbfe573054e3686416645261f8aa9 |
| Source note | uspto-grants-2001_12 |