Sodium borohydride → 3-{[1-(3,5-Difluorophenyl)ethylamino]-(4-methoxyphenyl)methyl}-4-methoxyphenylamine

Participants

Reaction Steps

Following a reaction and purification procedure similar to those described in Example (59b), 1.75 g of N-[1-(3,5-difluorophenyl)ethyl]-N-[(2-methoxy-5-nitrophenyl)-(4-methoxyphenyl)methyl]amine [prepared as described in step (a) above], 2.24 g of nickel chloride hexahydrate and 651 mg of sodium borohydride were reacted, to obtain 471 mg of isomer A and 650 mg of isomer B of the title compound were obtained as a yellow oil and an orange solid, respectively.

Provenance & Evidence