HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[(R)-1-(3,5-Difluorophenyl)ethyl]-N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (4-Methoxyphenyl)(3-nitrophenyl)methanone | HCID 794540 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | (1R)-1-(3,5-difluorophenyl)ethan-1-amine hydrochloride | HCID 44828509 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-[(R)-1-(3,5-Difluorophenyl)ethyl]-N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]amine | HCID 70189169 | — |
Reaction Steps
Following a reaction and purification procedure similar to those described in Example (1a), 4.42 of 4-methoxyphenyl 3-nitrophenyl ketone, 4.42 g of (R)-1-(3,5-difluorophenyl)ethylamine hydrochloride, 11.7 ml of triethylamine, 2.01 ml of titanium tetrachloride, 4.25 g of sodium cyanoborohydride and 1.31 ml of acetic acid were reacted, to obtain 860 mg of the more polar isomer B of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-19a5e6c2483d4f36aba018bc6e95db09 |
| Source note | uspto-grants-2001_12 |