HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[1-(3,5-Difluorophenyl)ethyl]-N-[(4-ethoxyphenyl)-(3-nitrophenyl)methyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (4-Ethoxyphenyl)(3-nitrophenyl)methanone | HCID 868593 | — |
| Reactant | (RS)-1-(3,5-Difluorophenyl)ethylamine | HCID 2783196 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-[1-(3,5-Difluorophenyl)ethyl]-N-[(4-ethoxyphenyl)-(3-nitrophenyl)methyl]amine | HCID 18334176 | 92.7% |
Reaction Steps
Following a similar procedure to that described in Example (1a), 1.0 g of 4-ethoxyphenyl 3-nitrophenyl ketone, 1.16 g of 1-(3,5-difluorophenyl)ethylamine, 2.01 ml of triethylamine, 0.49 ml of titanium tetrachloride, 975 mg of sodium cyanoborohydride and 0.32 ml of acetic acid were reacted, to obtain 1.41 g of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-ee7b100cb7f5415887b2980a55be218c |
| Source note | uspto-grants-2001_12 |