HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 3-{[1-(3,5-Difluorophenyl)ethylamino]-(4-ethoxyphenyl)methyl}phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | N-[1-(3,5-Difluorophenyl)ethyl]-N-[(4-ethoxyphenyl)-(3-nitrophenyl)methyl]amine | HCID 18334176 | — |
| Catalyst | Dichloronickel;hexahydrate | HCID 11791229 | — |
| Product | 3-{[1-(3,5-Difluorophenyl)ethylamino]-(4-ethoxyphenyl)methyl}phenylamine | HCID 18334234 | — |
Reaction Steps
Following a reaction and purification procedure similar to those described in Example (59b), 1.39 g of N-[1-(3,5-difluorophenyl)ethyl]-N-[(4-ethoxyphenyl)-(3-nitrophenyl)methyl]amine [prepared as described in step (a) above], 1.84 g of nickel chloride hexahydrate and 537 mg of sodium borohydride were reacted, to obtain 316 mg of isomer A and 531 mg of isomer B of the title compound as yellow oils, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-fd5b2615a2614e10b4832d4baf82206b |
| Source note | uspto-grants-2001_12 |