HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[1-(3,5-Difluorophenyl)ethyl]-N-[(3-nitrophenyl)-(4-isopropoxyphenyl)methyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (RS)-1-(3,5-Difluorophenyl)ethylamine | HCID 2783196 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 3-Nitrophenyl 4-isopropoxyphenyl ketone | HCID 18347067 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-[1-(3,5-Difluorophenyl)ethyl]-N-[(3-nitrophenyl)-(4-isopropoxyphenyl)methyl]amine | HCID 18334091 | 94.4% |
Reaction Steps
Following a similar procedure to that described in Example (1a), 850 mg of 3-nitrophenyl 4-isopropoxyphenyl ketone, 936 mg of 1-(3,5-difluorophenyl)ethylamine, 1.66 ml of triethylamine, 0.39 ml of titanium tetrachloride, 788 mg of sodium cyanoborohydride and 0.26 ml of acetic acid were reacted, to obtain 1.20 g of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-c65df999d2e146d598edb9a7bcb7d974 |
| Source note | uspto-grants-2001_12 |