HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[(R)-1-(3,5-Difluorophenyl)ethyl]-N-[(4-fluorophenyl)-(3-nitrophenyl)methyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 4-Fluoro-3'-nitrobenzophenone | HCID 10490558 | — |
| Reactant | (1R)-1-(3,5-difluorophenyl)ethan-1-amine hydrochloride | HCID 44828509 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-[(R)-1-(3,5-Difluorophenyl)ethyl]-N-[(4-fluorophenyl)-(3-nitrophenyl)methyl]amine | HCID 70189758 | 94.8% |
Reaction Steps
Following a similar procedure to that described in Example (1a), 3.0 g of 4-fluorophenyl 3-nitrophenyl ketone, 3.55 g of (R)-1-(3,5-difluorophenyl)ethylamine hydrochloride, 9.38 ml of triethylamine, 1.61 ml of titanium tetrachloride, 3.08 g of sodium cyanoborohydride and 1.05 ml of acetic acid were reacted, to obtain 4.48 g of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-bf6e55dcd2a64ce0b31df44de89a0a4d |
| Source note | uspto-grants-2001_12 |