HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 3-{(4-Chlorophenyl)-[1-(3,5-difluorophenyl)ethylamino]methyl}phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | N-[(4-Chlorophenyl)-(3-nitrophenyl)methyl]-N-[1-(3,5-difluorophenyl)ethyl]amine | HCID 18334265 | — |
| Catalyst | Dichloronickel;hexahydrate | HCID 11791229 | — |
| Product | 3-{(4-Chlorophenyl)-[1-(3,5-difluorophenyl)ethylamino]methyl}phenylamine | HCID 18334261 | — |
Reaction Steps
Following a reaction and purification procedure similar to those described in Example (59b), 2.79 g of N-[(4-chlorophenyl)-(3-nitrophenyl)methyl]-N-[1-(3,5-difluorophenyl)ethyl]amine [prepared as described in step (a) above], 3.79, of nickel chloride hexahydrate and 1.10 g of sodium borohydride were reacted, to obtain 808 mg of isomer A and 572 mg of isomer B of the title compound as colorless oils, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-1784621cc6d4468c9b11f7a91e1b4a7c |
| Source note | uspto-grants-2001_12 |