HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[1-(3,4-Difluorophenyl)ethyl]-N-[(2-fluoro-5-nitrophenyl)-(4-methoxyphenyl)methyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | Benzenemethanamine, 3,4-difluoro-α-methyl-, hydrochloride (1:1) | HCID 18347113 | — |
| Reactant | 2-Fluoro-5-nitrophenyl 4-methoxyphenyl ketone | HCID 70189764 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-[1-(3,4-Difluorophenyl)ethyl]-N-[(2-fluoro-5-nitrophenyl)-(4-methoxyphenyl)methyl]amine | HCID 18334198 | 68.7% |
Reaction Steps
Following a similar procedure to that described in Example (1a), 828 mg of 2-fluoro-5-nitrophenyl 4-methoxyphenyl ketone, 1.16 g of 1-(3,4-difluorophenyl)ethylamine hydrochloride, 2.52 ml of triethylamine, 0.40 ml of titanium tetrachloride, 840 mg of sodium cyanoborohydride and 0.62 ml of acetic acid were reacted, to obtain 860 mg of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-ee39a17ebafd4c8897483ad36ca76c64 |
| Source note | uspto-grants-2001_12 |