HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[1-(3,4-Dimethylphenyl)ethyl]-N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (4-Methoxyphenyl)(3-nitrophenyl)methanone | HCID 794540 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 1-(3,4-Dimethylphenyl)ethan-1-amine hydrochloride | HCID 18347123 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-[1-(3,4-Dimethylphenyl)ethyl]-N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]amine | HCID 18347035 | 95.5% |
Reaction Steps
Following a similar procedure to that described in Example (1a), 1.0 g of 4-methoxyphenyl 3-nitrophenyl ketone, 1.44 g of 1-(3,4-dimethylphenyl)ethylamine hydrochloride, 3.25 ml of triethylamine, 0.51 ml of titanium tetrachloride, 1.03 g of sodium cyanoborohydride and 0.33 ml of acetic acid were reacted, to obtain 1.45 g of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-12901b3dc33741d69dae9db3d1b7ff69 |
| Source note | uspto-grants-2001_12 |