Sodium borohydride → HCID 18334115, compound

HRID 2269473Notes

Reaction equation

HRID 2269473 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:12][CH:13]([C:23]2[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-])=O)[CH:15]=2)[CH2:10][CH3:11])[CH:5]=[CH:6][C:7]=1[F:8].[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:12][CH:13]([C:23]2[CH:24]=[CH:25][C:26]([O:29][CH3:30])=[CH:27][CH:28]=2)[C:14]2[CH:15]=[C:16]([NH2:20])[CH:17]=[CH:18][CH:19]=2)[CH2:10][CH3:11])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 18347063HCID 18347063, compound

Product 1

HCID 18334115HCID 18334115, compound

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a similar procedure to that described in Example (1b), 3.17 go N-[1-(3,4-difluorophenyl)propyl]-N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]amine [prepared as described in step (a) above], 3.66 g, of nickel chloride hexahydrate and 1.17 g of sodium borohydride were reacted, to obtain 2.76 of the title compound as a pale yellow oil.

Sources & evidence

ORD record
ord-16adad1bfd0c4724a69066691e9fe040
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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