Sodium borohydride → HCID 18334100, compound

HRID 2269475Notes

Reaction equation

HRID 2269475 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:11][CH:12]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[C:13]2[CH:18]=[C:17]([N+:19]([O-])=O)[CH:16]=[CH:15][C:14]=2[O:22][CH3:23])[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8].[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:11][CH:12]([C:24]2[CH:25]=[CH:26][C:27]([F:30])=[CH:28][CH:29]=2)[C:13]2[CH:18]=[C:17]([NH2:19])[CH:16]=[CH:15][C:14]=2[O:22][CH3:23])[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 18334191HCID 18334191, compound

Product 1

HCID 18334100HCID 18334100, compound

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a similar procedure to that described in Example (1b), 660 mg of isomer B of N-[1-(3,4-difluorophenyl)ethyl]-N-[(4-fluorophenyl)-(2-methoxy-5-nitrophenyl)methyl]amine [prepared as described in step (a) above], 762 mg of nickel chloride hexahydrate and 243 mg of sodium borohydride were reacted, to obtain 332 mg of isomer B of the title compound as a pale yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-026ceb713e73432ab370af957816b327
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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