Sodium borohydride → 3-{[(R)-1-(3-Fluorophenyl)ethylamino]-(4-methoxyphenyl)methyl}phenylamine

Participants

Reaction Steps

Following a similar procedure to that described in Example (59b), 15.08 g of N-[(R)-1-(3-fluorophenyl)ethyl]-N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]amine [prepared as described in step (a) above], 18.84 g of nickel chloride hexahydrate, 6.0 g of sodium borohydride and 150 ml of methanol were reacted, to obtain 787 mg and 605 mg of isomer A and isomer B of the title compound, respectively, each as a pale yellowish oil.

Provenance & Evidence