HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[(4-Chlorophenyl)-(3-nitrophenyl)methyl}-N-[(R)-1-(3-fluorophenyl)ethyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Chloro-3'-nitrobenzophenone | HCID 767346 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | (R)-1-(3-Fluorophenyl)ethylamine hydrochloride | HCID 45072322 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-[(4-Chlorophenyl)-(3-nitrophenyl)methyl}-N-[(R)-1-(3-fluorophenyl)ethyl]amine | HCID 70190114 | 96.6% |
Reaction Steps
Following a similar procedure to that described in Example (1a), 880 mg of 4-chlorophenyl 3-nitrophenyl ketone, 886 mg of (R)-1-(3-fluorophenyl)ethylamine hydrochloride, 2.58 ml of triethylamine, 0.44 ml of titanium tetrachloride, 890 mg of sodium cyanoborohydride and 0.29 ml of acetic acid were reacted, to obtain 1.25 g of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-e213ade1e1fd49218008440efc1d9440 |
| Source note | uspto-grants-2001_12 |