HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-3'-nitrobenzophenone → N-[(4-Chlorophenyl)-(3-nitrophenyl)methyl]-N-[(R)-1-(3,4-difluorophenyl)ethyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-3'-nitrobenzophenone | HCID 767346 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | (R)-1-(3,4-Difluorophenyl)ethanamine hydrochloride | HCID 45072357 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-[(4-Chlorophenyl)-(3-nitrophenyl)methyl]-N-[(R)-1-(3,4-difluorophenyl)ethyl]amine | HCID 70189351 | 92.2% |
Reaction Steps
Following a similar procedure to that described in Example (1a), 1.0 g of 4-chlorophenyl 3-nitrophenyl ketone, 1.11 g of (R)-1-(3,4-difluorophenyl)ethylamine hydrochloride, 2.93 ml of trietlaylamine, 0.50 ml of titanium tetrachloride, 1.01 g of sodium cyanoborohydride and 0.33 ml of acetic acid were reacted, to obtain 1.42 g of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-ea8db1aa97a04678a86bb37c88bdd8c7 |
| Source note | uspto-grants-2001_12 |