HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 3-{(4-Chlorophenyl)-[(R)-1-(3,4-difluorophenyl)ethylamino]methyl}-phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | N-[(4-Chlorophenyl)-(3-nitrophenyl)methyl]-N-[(R)-1-(3,4-difluorophenyl)ethyl]amine | HCID 70189351 | — |
| Catalyst | Dichloronickel;hexahydrate | HCID 11791229 | — |
| Product | 3-{(4-Chlorophenyl)-[(R)-1-(3,4-difluorophenyl)ethylamino]methyl}-phenylamine | HCID 70189151 | 99.7% |
Reaction Steps
Following a similar procedure to that described in Example (1b), 1.30 g of N-[(4-chlorophenyl)-(3-nitrophenyl)methyl]-N-[(R)-1-(3,4-difluorophenyl)ethyl]amine [prepared as described in step (a) above], 1.53 g of nickel chloride hexahydrate and 514 mg of sodium borohydride were reacted, to obtain 1.20 g of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-6eda80ae49274b489e0472f4193dea0e |
| Source note | uspto-grants-2001_12 |