Stannous Chloride → HCID 18347130, compound

HRID 2269513Notes

Reaction equation

HRID 2269513 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][C:27]=1[F:28])[CH2:5][NH:6][CH:7]([C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-])=O)[CH:9]=1.[Sn](Cl)Cl>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][C:27]=1[F:28])[CH2:5][NH:6][CH:7]([C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=1)[C:8]1[CH:9]=[C:10]([NH2:14])[CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 24479Stannous ChlorideHCID 18334142HCID 18334142, compound

Product 1

HCID 18347130HCID 18347130, compoundYield 113.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following a similar procedure to that described in Example (94b), 12.68 g of N-(3,4-difluorobenzyl)-N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]amine [prepared as described in step (a) above]. 25.03 g of tin (II) chloride and 120 ml of ethanol were reacted, to obtain 13.32 g of the title compound as a pale yellow oil.

Sources & evidence

ORD record
ord-58fa881060a342ae9f1ea366a75ccdec
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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