Sodium borohydride → HCID 70189745, compound

HRID 2269517Notes

Reaction equation

HRID 2269517 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([N+:24]([O-])=O)[CH:19]=2)[NH:9][C@@H:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH3:11])=[CH:4][CH:3]=1.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([NH:9][C@@H:10]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH3:11])[C:18]2[CH:19]=[C:20]([NH2:24])[CH:21]=[CH:22][CH:23]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 70189147HCID 70189147, compound

Product 1

HCID 70189745HCID 70189745, compound

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a procedure similar to that described in Example (1b), 710 mg of isomer B of N-[(4-chlorophenyl)-(3-nitrophenyl)methyl]-N-[(R)-1-phenylethyl]amine [prepared as described in step (a) above], 920 mg of nickel chloride hexahydrate and 293 mg of sodium borohydride were reacted and purified, to obtain 620 mg of isomer B of the title compound as a colorless oil.

Workup

  1. customwere reacted
  2. custompurified

Sources & evidence

ORD record
ord-86f5ab3b57204a2a8768d4a1c4911753
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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