HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[(R)-1-(3,4-difluorophenyl)ethyl]-N-[(3-nitrophenyl)phenylmethyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Nitrobenzophenone | HCID 75243 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | (R)-1-(3,4-Difluorophenyl)ethanamine hydrochloride | HCID 45072357 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-[(R)-1-(3,4-difluorophenyl)ethyl]-N-[(3-nitrophenyl)phenylmethyl]amine | HCID 70189165 | 87% |
Reaction Steps
Following a procedure similar to that described in Example (1a), 1.0 g of 3-nitrophenyl phenyl ketone, 1.24 g of (R)-1-(3,4-difluorophenyl)ethylamine hydrochloride, 3.27 ml of triethylamine, 0.56 ml of titanium tetrachloride, 1.13 g of sodium cyanoborohydride and 0.37 ml of acetic acid were reacted, to obtain 1.41 g of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-080291af66664bfd92723a32c4324223 |
| Source note | uspto-grants-2001_12 |