HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 3-{(4-Fluorophenyl)-[(R)-1-phenylethylamino]methyl}phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | HCID 70188094 | HCID 70188094 | — |
| Catalyst | Dichloronickel;hexahydrate | HCID 11791229 | — |
| Product | 3-{(4-Fluorophenyl)-[(R)-1-phenylethylamino]methyl}phenylamine | HCID 70189340 | — |
Reaction Steps
Following a procedure similar to that described in Example (59b), 3.90 g of N-[(4-fluorophenyl)-(3-nitrophenyl)methyl]-N-[(R)-1phenylethyl]amine [prepared as described in step (a) above], 5.29 g of nickel chloride hexahydrate and 1.68 g of sodium borohydride were reacted, separated and purified, to obtain 1.24 g of isomer A and 848 mg of isomer B of the title compound, each as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-0cc105ba738d49a68a543f271aded2c5 |
| Source note | uspto-grants-2001_12 |