Sodium Hydroxide → HCID 66758567, compound

HRID 2269552Notes

Reaction equation

HRID 2269552 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:39])[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH:16]=[C:17]3[C:27]4[C:22](=[N:23][CH:24]=[CH:25][CH:26]=4)[O:21][C:20]4[CH:28]=[CH:29][CH:30]=[C:31]([O:32][CH2:33][C:34]([O:36]CC)=[O:35])[C:19]=4[CH2:18]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[C:34]([CH2:33][O:32][C:31]1[C:19]2[CH2:18][C:17](=[CH:16][CH2:15][CH2:14][N:11]3[CH2:10][CH2:9][C:8]([C:5]4[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=4)([OH:39])[CH2:13][CH2:12]3)[C:27]3[C:22]([O:21][C:20]=2[CH:28]=[CH:29][CH:30]=1)=[N:23][CH:24]=[CH:25][CH:26]=3)([OH:36])=[O:35]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66758249HCID 66758249, compound

Product 1

HCID 66758567HCID 66758567, compoundYield 91.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of product of example 48 (3.0 g) in methanol (50 ml) was added 1N sodium hydroxide solution (8 ml) and the mixture stirred at room temperature for 1 hour. The reaction mixture was distilled off under reduced pressure. The residue was dissolved with water and neutralized with iN hydrochloric acid. The precipitation was filtered and washed with water to give the titled compound (2.6 g).

Workup

  1. distillationThe reaction mixture was distilled off under reduced pressure
  2. dissolutionThe residue was dissolved with water and neutralized with iN hydrochloric acid
  3. customThe precipitation
  4. filtrationwas filtered
  5. washwashed with water

Sources & evidence

ORD record
ord-91006498b3a648a4a0cbf35344e1bbba
Source dataset
uspto-grants-2001_12
Patent number
US06329385B1

Reaction notes

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