Sodium Hydroxide → HCID 15337394, compound

Participants

Reaction Steps

A mixture of 2-bromo-3-(4-(methanesulfonyl)phenyl) benzo-[b]thiophene (400 mg) from Step 3, phenylboric acid (590 mg), Pd (PPh3)4 (89 mg) and 1 molar NaOH in toluene (6 mL) and EtOH (8 mL) was refluxed for 24 hrs. After cooling to 25° C. a saturated NaHCO3 solution was added and the mixture was extracted with Et2O (2×), the organic portions were combined, washed with brine, dried over MgSO4, filtered and the solvent evaporated under vacuum. Purification by column chromatography using 2% isopropanol in hexane afforded the title compound. m.p. 172.9-173.9° C.

Provenance & Evidence