Hydrochloric Acid → HCID 22405886, compound

Participants

Reaction Steps

A mixture of 400 mg of the product of Step 6, 10 g of n-Bu4NOAcin 10 mL of THF were stirred at room temperature for 2 h. The reaction mixture was diluted with 50 mL of 3:2 THF/H2O and treated with 10 mL of 1N LiOH for 8 h. The reaction mixture was poured into a mixture of 20 mL of sat. NaCl and 10 mL of 2N HCl, and then extracted with 100 mL of EtOAc. The extract was dried over MgSO4 and concentrated in vacuo. The crude product was purified by flash chromatography and eluted with 19:1 EtOAc/AcOH to yield 250 mg of the title compound.

Provenance & Evidence