HCID 178500771, compound → HCID 57754580, compound

Participants

Reaction Steps

273 g (0.88 mmol) of 2-(3,4-Dimethyl-benzoyl)-3-(pyridine-4-ylamino)-acrylic acid methyl ester 2f was dissolved in 30 mL of diphenyl ether and the resultant solution was heated at 250° C. After 2.5 h, the reaction solution was cooled to room temperature and diluted with 50 mL of hexane. The crude product precipitated out of solution and was isolated by filtration. The crude product was purified by washing with hexane to yield 119 mg of 3-(3,4-Dimethyl-benzoyl)-1H-[1,6]napthyridin-4-one 10a as white crystals.

Provenance & Evidence