HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butylamine → Boc-Thz-NH-tBu
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 3-(1,1-Dimethylethyl) 3,4-thiazolidinedicarboxylate | HCID 5147014 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Boc-Thz-NH-tBu | HCID 54130109 | — |
Reaction Steps
In a DMF solution containing 0.10 g of N-(t-butoxy-carbonyl)-1,3-thiazolidine-4-carboxylic acid, 45 μl of tert-butylamine, 66 mg of HOBt and 98 mg of EDC hydrochloride were added under ice cooling and the resultant mixture was stirred for 14 hr. The reaction mixture was treated similarly to that in Example 34 (Process 3) to give 90 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329502B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-0de970e6ce984da59722c8e010071989 |
| Source note | uspto-grants-2001_12 |