HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → Boc-Thz piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | (4R)-3-[(tert-butoxy)carbonyl]-1,3-thiazolidine-4-carboxylic acid | HCID 688405 | — |
| Reactant | 2-Chloro-1,3-dimethylimidazolidin-1-ium;hexafluorophosphate | HCID 21868419 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | Boc-Thz piperidine | HCID 131722960 | — |
Reaction Steps
In a methylene chloride solution containing 300 mg of Boc-Thz-OH, 358 μl of triethylamine, 358 mg of 2-chloro-1, 3-dimethylimidazolidinium hexafluorophosphate and 153 μl of piperidine were added under ice cooling and the resultant mixture was stirred for 14 hr. The reaction mixture was treated similarly to that in Example 33 (Process 3) to give 300 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329502B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-4c5eb441d9bc4570877ded71086296d7 |
| Source note | uspto-grants-2001_12 |