HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Boc-Thz-Valol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | (4R)-3-[(tert-butoxy)carbonyl]-1,3-thiazolidine-4-carboxylic acid | HCID 688405 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | Boc-Thz-Valol | HCID 131722961 | — |
Reaction Steps
Deprotection of 94 mg of the compound obtained by the process 1 was performed similarly to that in Example 30 (Process 2), and the obtained product was dissolved in 3 ml of DMF and neutralized with 88.9 μl of triethylamine under ice cooling. To the neutralized solution, 164 mg of Boc-Thz-OH, 108 mg of HOBt and 147 mg of EDC hydrochloride were added and the resultant mixture was stirred for 2 hr. The reaction mixture was treated similarly to that in Example 132 (Process 1) to give 50 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329502B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-4844081a39884f509a4e9b84dfe0bbb3 |
| Source note | uspto-grants-2001_12 |