HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → (S)-tert-butyl 2-amino-2-oxo-1-phenylethylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | Azane;hydrate | HCID 12896473 | — |
| Reactant | N-(tert-Butoxycarbonyl)-N-phenylglycine | HCID 21905636 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-tert-butyl 2-amino-2-oxo-1-phenylethylcarbamate | HCID 11128727 | 15.1% |
Reaction Steps
In a dichloromethane solution containing 4.3 g of N-(tert-butoxycarbonyl)phenylglycine, 5 ml of ammonia water, 1.5 g of HOBt and 23 g of EDC hydrochloride were added under ice cooling and the resultant mixture was stirred overnight at room temperature. The reaction mixture was treated similarly to that in Example 144 (Process 2) to give 0.42 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329502B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-213ec1f4a11b4962b222d46e87d72f15 |
| Source note | uspto-grants-2001_12 |