反应详情

温度

25 °C

2-Chloro-6-fluorobenzthioamide (21.9 g, 0.12 mol) and dimethyl sulfate (12 mL, 16.0 g, 0.13 mol) were stirred together in 100 mL of toluene and refluxed for 2 h. The slurry was cooled to 25° C. and the white crystals collected on a glass buchner funnel and rinsed with a small quantity of acetone. After air suction drying for 1 h, 35.5 g of methyl 2-chloro-6-fluorobenzthioimidate methylsulfate salt was obtained, mp 147-151° C., representing a nominal wt. % yield of 96%.

1. temperaturerefluxed for 2 h
2. customthe white crystals collected on a glass buchner funnel
3. washrinsed with a small quantity of acetone
4. customAfter air suction drying for 1 h