反应详情

Lawesson's reagent (2.6 g) was added to a toluene (10 ml) solution of methyl succinamate (1.7 g). The reaction mixture was heated under reflux for 4 hours, cooled, and then concentrated. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=1/1) to obtain the entitled compound (400 mg) as an oily substance.

1. temperatureThe reaction mixture was heated
2. temperatureunder reflux for 4 hours
3. temperaturecooled
4. concentrationconcentrated
5. customThe residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=1/1)