反应详情

10% Palladium- carbon (0.2 g) was added to an ethanol solution (20 ml) of ethyl 3-(2-nitrobenzyl)-2-oxo-1-propyl-3-piperidinecarboxylate (1.00 g), and catalytic hydrogenation was conducted at room temperature under one atmospheric pressure for 6 hours. The catalyst was removed by filtration and the filtrate was concentrated. The residue was dissolved in toluene (20 ml), which was heated under reflux for 12 hours. The reaction mixture was concentrated, and the obtained crude crystals were recrystallized from ethyl acetate-hexane to give the entitled compound (0.55 g).

1. customThe catalyst was removed by filtration
2. concentrationthe filtrate was concentrated
3. dissolutionThe residue was dissolved in toluene (20 ml)
4. temperaturewhich was heated
5. temperatureunder reflux for 12 hours
6. concentrationThe reaction mixture was concentrated
7. customthe obtained crude crystals
8. customwere recrystallized from ethyl acetate-hexane