Sodium Carbonate → HCID 18332948, compound

Participants

Reaction Steps

To a suspension of ethyl 7-amino-2-oxo-1,2,3,4-tetrahydro-3-quinolinecarboxylate (2.0 g) in THF(40 ml) was added aqueous sodium carbonate (4.5 g in 40 ml) and cooled, to which benzylchloroformate (1.8 ml) was added dropwise. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, dried, and concentrated. The precipitated crystals were washed with hexane to obtain the entitled compound (3.07 g).

Provenance & Evidence