Hydrochloric Acid → HCID 18333029, compound

Participants

Reaction Steps

To a solution of ethyl 7-benzyloxycarbonylamino-2-oxo-1,2,3,4-tetrahydro-3-quinolinecarboxylate (7.8 g) in a mixed solvent of THF (80 ml) and methanol (80 ml) was added 1N aqueous sodium hydroxide (32 ml) under 10° C. The reaction mixture was stirred at room temperature for 4 hours, to which was added 1N hydrochloric acid (35 ml) under 1° C. The reaction mixture was diluted with a saturated aqueous sodium chloride solution and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, dried, and concentrated to obtain the entitled compound (7.20 g).

Provenance & Evidence