Hydrochloric Acid → HCID 18332940, compound

Participants

Reaction Steps

10% Pd-C (175 mg) and concentrated hydrochloric acid (0.3 ml) were added to a methanol (15 ml) solution of 4-benzyl-2-(N,N-dimethylamino)methyl-1-formyl-1,2,3,4-tetrahydroquinoxaline (350 mg). The reaction mixture was subjected to catalytic hydrogenation at room temperature under 4.5 atmospheric pressure for 2 hours. The catalyst was removed by filtration and the filtrate was concentrated. 10% Aqueous potassium carbonate solution was added to the residue, which was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, then dried and concentrated to give 2-(N,N-dimethylamino)methyl-1-formyl-1,2,3,4-tetrahydroquinoxaline (190 mg).

Provenance & Evidence