Methanol → HCID 18333081, compound

Participants

Reaction Conditions

Reaction Steps

4N Hydrochloric acid-ethyl acetate (2 ml) was added to a methanol (10 ml) solution of 4-(3-(4-biphenylyl)propanoyl)-1-formyl-2-(pyrrolidin-1-yl)methyl-1,2,3,4-tetrahydroquinoxaline (320 mg). The reaction mixture was stirred at 50° C. for one hour, then concentrated. 10% Aqueous potassium carbonate solution was added to the residue, which was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, then dried and concentrated. The residue was purified by alumina column chromatography (eluent: hexane to hexane/ethyl acetate=7/1), which was converted into its oxalate. The obtained crystals were washed with methanol-IPE to give the entitled compound (250 mg).

Provenance & Evidence