Sodium Hydroxide → HCID 70215476, compound

Participants

Reaction Conditions

Reaction Steps

Into 150 ml of methanol, 15.0 g (53.9 mmol) of (E) ethyl 3-(4-dimethylamino-2-nitrophenyl)-2-methyl-2-propenate were dissolved; and, with 3.2 g (80 mmol) of sodium hydroxide being added thereto, the mixture was stirred at 45° C. for 5.5 hours. After the solvent was evaporated from the reaction liquid under a reduced pressure, the residue was dissolved in 100 ml of water. Thus obtained solution was adjusted to neutral with 2-N hydrochloric acid being added thereto. The precipitated crystal was filtered out, fully washed with water, and then dried, whereby 12.1 g of the aimed compound were obtained as a crystal (yield: 89.7%).

Provenance & Evidence