3-(2-Amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid ethyl ester → 6,7-Dimethoxy-3-methyl-carbostyril

HRID 2269781Notes

Reaction equation

HRID 2269781 reaction equation
C([O:3][C:4](=O)[C:5]([CH3:18])=[CH:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[C:10]([O:15][CH3:16])=[CH:9][C:8]=1[NH2:17])C>C(O)C>[CH3:14][O:13][C:11]1[CH:12]=[C:7]2[C:8](=[CH:9][C:10]=1[O:15][CH3:16])[NH:17][C:4](=[O:3])[C:5]([CH3:18])=[CH:6]2

Participants

3

Reactant 1

HCID 702131123-(2-Amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid ethyl ester

Product 1

HCID 183480236,7-Dimethoxy-3-methyl-carbostyrilYield 92%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Into 30 ml of ethyl alcohol, 0.5 g of 3-(2-amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid ethyl ester was dissolved. This solution was irradiated with ultraviolet rays at 365 nm for about 20 hours, and the precipitated crystal was filtered out. This crystal was recrystallized from ethanol, whereby 0.38 g of the aimed compound was obtained (yield: 92%).

Workup

  1. customThis solution was irradiated with ultraviolet rays at 365 nm for about 20 hours
  2. filtrationthe precipitated crystal was filtered out
  3. customThis crystal was recrystallized from ethanol

Sources & evidence

ORD record
ord-d163b67745eb45f392d832254474f72a
Source dataset
uspto-grants-2001_12
Patent number
US06329546B1

Reaction notes

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