HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 5-nitro-2-(2-methoxy-6-methoxymethoxyphenyl)-benzoate → Methyl 5-amino-2-(2-methoxy-6-methoxymethoxyphenyl)-benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 5-nitro-2-(2-methoxy-6-methoxymethoxyphenyl)-benzoate | HCID 18189455 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 5-amino-2-(2-methoxy-6-methoxymethoxyphenyl)-benzoate | HCID 18188782 | — |
Reaction Steps
A solution of Example 32A (10.0 g) and 10% Pd/C (1.0 g) in methanol (200 mL) at room temperature was hydrogenated at 4 atm for 1 hour, filtered through diatomaceous earth (Celite®), and concentrated to provide the desired product. MS (ESI(−)Q1MS) m/z 316 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329534B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-c232fd25a5554fa7a446b8273a76a924 |
| Source note | uspto-grants-2001_12 |