Cesium carbonate → HCID 57189547, compound

Participants

Reaction Steps

Combine N,N′-diphenethyl-2-((S)-2-bromo-6-phthalimidohexanoylamino)malonamide (10 mmol), 4-methyoxybenzylmercaptan (3.48 mL, 25 mmol), and tetrabutylammonium iodide (about 50 mg) in dimethylformamide (10 mL). Degas by repeatedly applying vacuum and filling the vessel with nitrogen. Add cesium carbonate (4.10 g, 12.5 mmol). After 15 hours, partition the reaction mixture between water and methyl t-butyl ether, saturate the aqueous layer with sodium chloride. Extract the aqueous layer with brine, dry over Na2SO4, filter, and evaporate in vacuo to give the title compound.

Provenance & Evidence