Tetrahydrofuran → HCID 15542675, compound

Participants

Reaction Steps

Combine 1-(3,4,5-trimethoxy-benzoyl)-3-[2-[4-[1-(4-fluoro-benzyl)-1 H-benzoimidazole-2-carbonyl]-piperidin-1-yl]-ethyl]-3-(4-(t-butyldimethylsilyloxy)-phenyl)-pyrrolidine (6 mmol) and THF (20 mL). Cool using an ice bath. Add dropwise, a 1 M THF solution of tetrabutylammonium fluoride (7 mL). After 30 minutes, concentrate in vacuo to obtain a residue. Combine dichloromethane (50 mL) and the residue. Extract with water (3×15 mL), dry the organic layer over Na2SO4, filter, and concentrate in vacuo to obtain a residue. Chromatograph on silica gel to obtain the title compound.

Provenance & Evidence