Oxalyl chloride → 3-Isopropoxy-phenyl-acetyl chloride

Participants

Reaction Conditions

Reaction Steps

Combine 3-isopropoxy-phenyl-acetic acid (0.5 g, 2.6 mmol) and dichloromethane (5 mL). Cool to −5° C. using a salt-ice bath. Add 2 drops of dimethylformamide followed by dropwise addition of oxalyl chloride (0.34 g, 2.7 mmol). After 1 hour, warm the reaction mixture to ambient temperature. After 2 hours, evaporate the reaction mixture in vacuo to give the title compound as a liquid.

Provenance & Evidence