1-(3,4,5-Trimethoxy-benzoyl)-3-phenyl-3-(2-methanesulfonyl-ethyl)-pyrrolidine → 1-(3,4,5-trimethoxy-benzoyl)-3-[2-[4-[1H-benzoimidazole-2-carbonyl]-piperidin-1-yl]-ethyl]-3-phenyl-pyrrolidine

Participants

Reaction Steps

Prepare by the method of Example 6.6.2 using 1-(3,4,5-trimethoxy-benzoyl)-3-phenyl-3-(2-methanesulfonyl-ethyl)-pyrrolidine and 4-(1 H-benzoimidazole-2-carbonyl)-piperidine hydroiodide salt to give the title compound: mp; 108.0-111.0° C.; Rf=0.28 (silica gel, 5/1 ethyl acetate/methanol) Elemental Analysis calculated for C35H40N4O5·0.30 H2O: C 69.82; H 6.80; N 9.30; Found: C 69.90; H 6.79; N 9.22.

Provenance & Evidence