Diphenylmethyl 4-(ethyl acetoxy)-3,5-dimethoxybenzoate → 4-(Ethyl acetoxy)-3,5-dimethoxybenzoic acid

Participants

Reaction Steps

Combine diphenylmethyl 4-(ethyl acetoxy)-3,5-dimethoxybenzoate (4.3 g, 9.56 mmol), 5% palladium-on-carbon (0.5 g), and ethanol/ethyl acetate/dichloromethane (200 mL/15 mL/15 mL). Hydrogenate at an initial pressure of 55 psi in a Parr apparatus. After 16 hours, filter and concentrate the filtrate to give a residue. Recrystallize the residue from diethyl ether/hexane to give the title compound: Rf=0.35 (silica gel, 6% methanol/dichloromethane).

Provenance & Evidence