HCID 15228076, compound → 1-(3,4,5-Trimethoxy-benzoyl)-3-[2-[4-[1-(2-ethoxy-ethyl)-1H-benzoimidazole-2-carbonyl]-piperidin-1-yl]-ethyl]-3-(pyridin-2-yl)-pyrrolidine

HRID 2269893Notes

Reaction equation

HRID 2269893 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:22]=[C:23]([O:27][CH3:28])[C:24]=1[O:25][CH3:26])[C:6]([N:8]1[CH2:12][CH2:11][C:10]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)([CH2:13][CH:14]=O)[CH2:9]1)=[O:7].[CH2:29]([O:31][CH2:32][CH2:33][N:34]1[C:38]2[CH:39]=[CH:40][CH:41]=[CH:42][C:37]=2[N:36]=[C:35]1[C:43]([CH:45]1[CH2:50][CH2:49][NH:48][CH2:47][CH2:46]1)=[O:44])[CH3:30]>>[CH3:28][O:27][C:23]1[CH:22]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[C:24]=1[O:25][CH3:26])[C:6]([N:8]1[CH2:12][CH2:11][C:10]([CH2:13][CH2:14][N:48]2[CH2:47][CH2:46][CH:45]([C:43]([C:35]3[N:34]([CH2:33][CH2:32][O:31][CH2:29][CH3:30])[C:38]4[CH:39]=[CH:40][CH:41]=[CH:42][C:37]=4[N:36]=3)=[O:44])[CH2:50][CH2:49]2)([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)[CH2:9]1)=[O:7]

Participants

3

Reactant 2

HCID 15228076HCID 15228076, compoundHCID 184644641-(3,4,5-Trimethoxybenzoyl)-3-(pyrid-2-yl)-3-(2-oxoethyl)pyrrolidine

Product 1

HCID 183332901-(3,4,5-Trimethoxy-benzoyl)-3-[2-[4-[1-(2-ethoxy-ethyl)-1H-benzoimidazole-2-carbonyl]-piperidin-1-yl]-ethyl]-3-(pyridin-2-yl)-pyrrolidine

Procedure

Prepare by the method of Example 68.2 using 1-(3,4,5-trimethoxy-benzoyl)-3-(pyridin-2-yl)-3-(2-oxo-ethyl)-pyrrolidine and 4-[1-(2-ethoxy-ethyl)-1H-benzoimidazole-2-carbonyl]-piperidine to give the title compound

Sources & evidence

ORD record
ord-8f56eeff95bf4eac9a359b5d313f992f
Source dataset
uspto-grants-2001_12
Patent number
US06329392B1

Reaction notes

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