HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[(5,6-Dimethyl-pyridin-2-ylamino)-methylene]-malonic acid diethyl ester → 6,7-Dimethyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[(5,6-Dimethyl-pyridin-2-ylamino)-methylene]-malonic acid diethyl ester | HCID 57754778 | — |
| Solvent | Diphenyl Ether | HCID 7583 | — |
| Product | 6,7-Dimethyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester | HCID 57754526 | 80.7% |
Reaction Steps
Experimental conditions analogous to those described for Step 2 of Example 60 were used with 10.61 g (36.29 mmol) of 2-[(5,6-Dimethyl-pyridin-2-ylamino)-methylene]-malonic acid diethyl ester and 150 mL of diphenyl ether to yield 7.21 g of 6,7-Dimethyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557213B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-167cfd949e774cc799af3b50b5ae9332 |
| Source note | uspto-grants-2009_07 |