Hydrochloric Acid → 193813-77-3

Participants

Reaction Steps

To a solution of 2-azido-4′-ethoxycarbonylactophenone (1.44 g), methanol (41.3 ml) and conc. hydrochloric acid (1.38 ml) was added 10% palladium-activated carbon (73 mg), and stirred for 3 hours in hydrogen atmosphere at 2.8 atm. After 1 hour, the reaction mixture was filtered off, and the filtrate was evaporated under reduced pressure. The solids were slurried in diisopropyl ether, and collected by filtration to give 2-amino-4′-ethoxycarbonylacetophenone hydrochloride (1.40 g).

Provenance & Evidence