Ammonium Acetate → HCID 15458590, compound

Participants

Reaction Steps

1.23 g of 2,3-dimethyl-4-chloro-8-methoxy-quinoline, 1 g of ammonium acetate, 20 ml of acetic acid and 1.2 g of palladium-on-charcoal (5%) are introduced into a Parr flask. The mixture is subjected to a hydrogen pressure of 50 psi for 4 h. The reaction medium is filtered and neutralized with 75 ml of 1 N sodium hydroxide. This mixture is extracted with ethyl acetate (2×75 ml). The organic phases are combined, dried over magnesium sulphate and concentrated. 1.32 g (yield: 77%) of 2,3-dimethyl-8-methoxyquinoline are obtained—m.p.: 138-139° C.

Provenance & Evidence