HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-2-methylpyridine → 3-(4-Methoxy-3-methyl-benzoyl)-6-methyl-1H-[1,5]naphthyridin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-2-methylpyridine | HCID 243313 | — |
| Reactant | 3-Ethoxy-2-(4-methoxy-3-methyl-benzoyl)-acrylic acid methyl ester | HCID 66878626 | — |
| Solvent | Diphenyl Ether | HCID 7583 | — |
| Product | 3-(4-Methoxy-3-methyl-benzoyl)-6-methyl-1H-[1,5]naphthyridin-4-one | HCID 57754706 | 56.9% |
Reaction Steps
Experimental conditions analogous to those described for Step 1 of Example 1 were used with 0.50 g (1.88 mmol) of 3-ethoxy-2-(4-methoxy-3-methyl-benzoyl)-acrylic acid methyl ester, 0.20 g (1.88 mmol) of 6-Methyl-pyridin-3-ylamine, and 10 mL of diphenyl ether to yield 0.33 g of 3-(4-Methoxy-3-methyl-benzoyl)-6-methyl-1H-[1,5]naphthyridin-4-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557213B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-2b9834e73ab544c49c9d92747a0ce5c9 |
| Source note | uspto-grants-2009_07 |