HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (+)-2-ethyl-3-methyl-8-(1(R)-diethylamino-2-hydroxyethyl)quinoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (+)-2-ethyl-3-methyl-8-(1(R)-diethylamino-2-hydroxyethyl)quinoline | HCID 15458597 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | (+)-2-ethyl-3-methyl-8-(1(R)-diethylamino-2-hydroxyethyl)quinoline hydrochloride | HCID 20714288 | — |
Reaction Steps
One equivalent of 0.1 N solution of hydrogen chloride in isopropanol is added to 250 mg of (+)-2-ethyl-3-methyl-8-(1(R)-diethylamino-2-hydroxyethyl)quinoline. The isopropanol is evaporated off and the product is recrystallized from acetone. 0.20 g of (+)-2-ethyl-3-methyl-8-(1(R)-diethylamino-2-hydroxyethyl)quinoline hydrochloride is obtained in the form of a white solid—m.p.: 1870° C. [α]D20=+2.01°(C=1, methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06331549B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-f805ce13c4914763a5d012e92ffc8547 |
| Source note | uspto-grants-2001_12 |